animal cells lose their totipotency at an early stage in embryonic development.
Examples of totipotency
totipotency
However, totipotency is lost as cleavage divisions progress and positional clues start to have a role.
From the nature.com
In this way, demethylation would be necessary for regenerating totipotency in the preimplantation embryo.
From the nature.com
According to Dr Lanza, the evidence from other mammals is that the individual cells of a developing embryo have lost totipotency by the eight-cell stage.