a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)
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secretase::noun | Spocien Dictionary
| Type | Words |
|---|---|
| Type of | enzyme |
Examples of secretase
secretase
One, known as LY2886721, blocks an enzyme, beta-secretase, used to make amyloid.
From the nytimes.com
Inoue et al have found a new target of gamma secretase, a protein called EphA4.
From the sciencedaily.com
Gamma-secretase enzymes generate toxic molecules called amyloid-beta peptides.
From the sciencedaily.com
The treatment molecule, beta-secretase inhibitor CTS-21166, is the culmination of this work.
From the sciencedaily.com
And BACE, the gene for an enzyme called beta secretase, is involved in Alzheimer's disease.
From the economist.com
It targets an enzyme called gamma secretase that is thought to be involved in making beta amyloid.
From the signonsandiego.com
Gamma-secretase, the enzyme targeted, can create beta amyloid.
From the dispatch.com
They say gamma secretase inhibitors now under development are much more selective and may be much safer.
From the nytimes.com
That step requires an enzyme called beta-secretase or BACE 1.
From the npr.org
- A set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)
- A group of enzymes found in brain cells (alpha-secretase, beta-secretase, and gamma-secretase. The secretases function to degrade APP. The abnormal degradation of APP can result in the accumulation of amyloid in the brain and the development of Alzheimer's disease.
