Ubiquitin is essentially a molecular tag that signals the proteosome to degrade the TIM protein.
From the sciencedaily.com
The researchers wanted to see if they could find a molecule that inhibited Usp14, thus allowing the proteosome to work effectively.
From the sciencedaily.com
Proteosome, in turn, is a large protein enzyme that breaks down oxidized proteins that would otherwise accumulate and cause cells to die.
From the sciencedaily.com
Using several assays on fly brain tissue, the team found that the proteosome, a cellular structure made from several proteins, plays a key role in TIM's degradation.
From the sciencedaily.com
Among these was ProScript Inc. ProScript discovered Velcade, an inhibitor of the proteosome, that has proved to be an effective treatment for multiple myeloma and other cancers.
From the en.wikipedia.org
While CHIP levels remain unchanged, the increased binding results in about half the receptors getting hauled to the cell's proteosome to be chopped up and degraded.
From the sciencedaily.com
More examples
Proteosome vaccine: a form of vaccine that can be administered by an inhaler
Proteasomes are very large protein complexes inside all eukaryotes and archaea, as well as in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. ...