In most cases, we have no way to tell whether a particular epigenetic signature is a cause of disease or merely a consequence of the pathological state.
From the nature.com
In light of the insurmountable certainty of universal doom, apathy is the default mode of existential nihilism, and, as such, is not considered to be a pathological state by those who experience it.
From the en.wikipedia.org
Government agencies assigned to police state roles invariably attract violent and pathological scum.
From the infowars.com
If he had taken mefloquine, and his mental state was further affected by alcohol and steroids, that could also lead to a defense of pathological intoxication.