Reduced blood flow causes the heart to demand more oxygen, resulting in damaging, oxidized LDL, the bad kind of cholesterol.
From the thenewstribune.com
These white blood cells are not able to process the oxidized-LDL, and ultimately grow then rupture, depositing a greater amount of oxidized cholesterol into the artery wall.
From the en.wikipedia.org
When LDL cholesterol interacts with free radicals to become oxidized, the cholesterol is more likely to promote inflammation and can cause tissue damage.
From the sciencedaily.com
To attract and stimulate macrophages, the cholesterol must be released from the LDL particles and oxidized, a key step in the ongoing inflammatory process.