Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway.
From the nature.com
Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue.
From the nature.com
Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo.
From the nature.com
The roles of osteocyte signaling in bone.
From the nature.com
In addition, low doses of GCs can induce self-preservation of osteocytes through the molecular mechanisms of autophagy, while higher doses of GCs induce osteocyte apoptosis.
From the nature.com
Osteocyte biology is complex and there remain many uncertainties regarding osteocyte function, as well as their mechanisms of communication with other cells and their effects on them.
From the nature.com
Additional studies are needed to further explore whether current treatments used for GC-induced bone loss alter osteocyte metabolism and how this influences localized and whole bone strength.