Genome-wide insertional mutagenesis of Arabidopsis thaliana.
From the nature.com
To deal with potential insertional mutagenesis, the vector integrations are then mapped to the human genome.
From the nature.com
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
From the nature.com
Although insertional mutagenesis is seen as an adverse effect of gene therapy, it can be exploited for cancer gene discovery.
From the bhdresearch.scienceblog.com
Insertional mutagenesis using gene therapy could be a valuable technique to identify cancer-associated genes that could be potential therapeutic targets.
From the bhdresearch.scienceblog.com
The use of diverse transposon systems with distinct target site preferences makes full genome coverage with transposon-based insertional mutagenesis a realistic goal.
From the nature.com
Protein delivery of these tools avoids the risk of insertional mutagenesis associated with delivery by viral vectors as well as the toxicity associated with the cellular response to exogenous RNA.