It gets its real kick from the protease inhibitor indinavir, approved last year.
From the sfgate.com
A mutation at position 46 makes the virus resistant to the drug indinavir.
From the newscientist.com
Consequently, there's not enough indinavir in the blood to do the job it's designed to do.
From the sciencedaily.com
Dosages of amprenavir, atazanavir, or indinavir may need to be increased.
From the en.wikipedia.org
They gave study volunteers a combination of the protease inhibitors ritonavir and indinavir.
From the sciencedaily.com
Indinavir belongs to a class of drugs known as protease inhibitors.
From the sciencedaily.com
John's wort is suspected to induce drug metabolism, which revs up the rate the liver eliminates indinavir from the body.
From the sciencedaily.com
One drug, indinavir, targets a protein called protease, which the virus needs to assemble the capsule it uses to invade new cells.
From the sciencedaily.com
They showed that administration of two protease inhibitor drugs, indinavir and saquinavir, greatly reduced the growth of KS lesions in mice.
From the nature.com
They based this recommendation on the significant benefit of the triple combination including indinavir in delaying disease progression and death.
From the sciencedaily.com
The NIH Clinical Center study, conducted among eight healthy volunteers, first measured the amount in the body of the drug indinavir when taken alone.
From the sciencedaily.com
John's wort and in indinavir are thought to share a metabolic pathway, which suggested the probability of the drugs'interaction, Piscitelli said.
From the sciencedaily.com
In these studies, Kharasch and his team looked at interactions among methadone, the P4503A enzyme in the intestine and liver and the protease inhibitors nelfinavir, indinavir and ritonavir.
From the sciencedaily.com
In addition, Kline found substantial amounts of indinavir in cerebrospinal fluid and an absence of HIV RNA, indicating there were antiviral effects within the central nervous system.
From the sciencedaily.com
Both ritonavir and indinavir belong to a promising new class of drugs called protease inhibitors, which block production of a key enzyme, protease, that the virus needs to replicate itself.
From the time.com
More examples
A protease inhibitor (trade name Crixivan) used for treating HIV
A drug that interferes with the ability of a virus to make copies of itself.
A protease inhibitor drug approved for the treatment of late-stage HIV disease. Current practice favors the use of indinavir in combination therapy (e.g., with nucleoside analog drugs) to avoid the development of drug-resistant virus.
An experimental protease inhibitor drug made by Merck pharmaceuticals
The generic name for Crixivan, one of the medications used to fight the Human Immunodeficiency Virus (see Crixivan).