All of these, except paroxysmal nocturnal hemoglobinuria, are hereditary genetic disorders.
From the en.wikipedia.org
In March 2007, Soliris was approved by the FDA for the treatment of the blood disease paroxysmal nocturnal hemoglobinuria, or PNH.
From the investors.com
Alexion's work on paroxysmal nocturnal hemoglobinuria, the disease that would make Soliris a blockbuster, began in the desperate, deep-in-the-red days.
From the forbes.com
For example, in 2006 Alexion Pharmaceuticals gained approval for Soliris, used for paroxysmal nocturnal hemoglobinuria, a blood disease so rare that it affects only about 4,000 Americans.
From the forbes.com
Additionally intravascular hemolysis causes destruction of red blood cells resulting in increase in free hemoglobin and hemoglobinuria which can lead to renal toxicity or renal failure.
From the en.wikipedia.org
More examples
Presence of hemoglobin in the urine
In medicine, hemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. ...