the specific target of the immune response in rheumatoid arthritis is filaggrin.
Examples of filaggrin
filaggrin
This gene encodes filaggrin, an essential protein in the horny layer of the skin.
From the sciencedaily.com
The two filaggrin mutations studied are present in 9% of people of European origin.
From the nature.com
Mutations in the gene for the protein filaggrin have been linked to asthma and eczema.
From the newscientist.com
Filaggrin is a protective protein normally found in skin.
From the sciencedaily.com
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
From the sciencedaily.com
The Munich scientists found that almost 8% of the children in Germany suffer from a genetically determined deficiency of filaggrin protein in the skin.
From the sciencedaily.com
The authors suggest that a loss of filaggrin leads to a defect in the skin barrier, which makes individuals susceptible to disease-triggering allergen transfer through the skin.
From the nature.com
Filaggrin, however, is only one of 150 to 200 genes that comprise the epidermal differentiation complex, which directs the formation of the skin's defensive barriers and cell growth more generally.
From the sciencedaily.com
More examples
The main protein of the keratohyalin granules; "the specific target of the immune response in rheumatoid arthritis is filaggrin"
Filaggrins are filament-associated proteins which bind to keratin fibers in epithelial cells.
Epidermal protein contained in keratohyalin granules (Granules found in living cells of keratinising epithelia and which contribute to the keratin content of the dead cornified cells).