Little is known about erythroblast parasitism in rodent malaria parasites.
From the nature.com
We next asked why erythroblast parasitism might be advantageous for malaria parasites.
From the nature.com
Erythropoietin modulation of podocalyxin and a proposed erythroblast niche.
From the nature.com
Erythroblast parasitism, for example, may suppress erythropoiesis.
From the nature.com
From a pathological point of view, erythroblast parasitism may partly contribute to the development of anemia, one of the major symptoms of malaria.
From the nature.com
Further study showed that GDF15 does indeed signal reduced hepcidin production in liver cells, and the study revealed additional erythroblast proteins that may be involved.
From the sciencedaily.com
The discovery could be translated into an experimental therapy by finding the molecule that physically binds a macrophage to an erythroblast, and then targeting and inhibiting it.
From the sciencedaily.com
The reason for parasite preference for the later stages of the erythroblast population might be due to the expression of receptor molecules on their surface ligated to merozoite molecules.
From the nature.com
The nucleus is expelled during the process of differentiation from an erythroblast to a reticulocyte, which is the immediate precursor of the mature erythrocyte.