Preventive treatment of cluster headaches may include drugs like verapamil, lithium, topiramate, and ergotamine.
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In pure form, the first ergot alkaloids, ergotamine and its isomer ergotaminine were isolated by Arthur Stoll in 1918.
From the en.wikipedia.org
Ergotamine tartrate, a precursor to lysergic acid, is regulated under the Chemical Diversion and Trafficking Act.
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The relationship between ergot and ergotism was established only in 1717, and the alkaloid ergotamine, one of the main active ingredients of ergot, was isolated in 1918.
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Beginning with ergotaminetartrate, for example, one can manufacture roughly one kilogram of pure, crystalline LSD from five kilograms of the ergotamine salt.
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Five kilograms of LSD-25 kilograms of ergotamine tartrate-could provide 100 million doses, according to the DEA, more than enough to meet what is believed to be the entire annual U.S. demand.
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More examples
An alkaloid derived from ergot that is less toxic than ergot; causes constriction of blood vessels and is used to treat migraine
Ergotamine is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. It possesses structural similarity to several neurotransmitters, and has biological activity as a vasoconstrictor. ...
(Ergotamines) Ergoline is a chemical compound whose structural skeleton is contained in a diverse range of alkaloids including a few psychedelic drugs (lysergic acid, LSD). ...
An alkaloid derived from ergot (fungus in the genus Claviceps), which narrows blood vessels (vasoconstriction). They sometimes relieve pain by reducing pressure on pain-sensitive structures that may be associated with cluster and/or migraine headaches. ...
A 3-amino acid cyclopeptide derivative of lysergic acid from Claviceps purpurea sclerotia; ergotamine tartrate is used to manage migraine by causing vasoconstriction of cranial arterioles, thereby reducing the pulsation pressure and attendant headache.
A drug used to prevent or treat migraine headaches. This can cause vomiting, diarrhea, and convulsions in infants.
A vasoconstrictor found in ergot of central europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine headaches. Pharmacological action: adrenergic alpha-agonists, analgesics, non-narcotic, vasoconstrictor agents. ...