In low doses, they stimulate the receptors, in high they numb them due to depolarisation block.
From the en.wikipedia.org
Secondly, the overall direction of travel of the wave of depolarisation can also be inferred which can reveal other problems.
From the en.wikipedia.org
Prior to this work, it was unclear which phosphoinositides were the major substrates of the phosphatase activity, and whether depolarisation or hyperpolarisation induced the phosphatase activity.
From the sciencedaily.com
More examples
Depolarization: a loss of polarity or polarization
In biology, depolarization is a change in a cell's membrane potential, making it more positive, or less negative. In neurons and some other cells, a large enough depolarization may result in an action potential. ...