The configurational entropy is also known as microscopic entropy or conformational entropy in the study of macromolecules.
From the en.wikipedia.org
Some techniques to calculate conformational entropy such as principal components analysis come from information theory.
From the en.wikipedia.org
The passage of the folded state is mainly guided by hydrophobic interactions, formation of intramolecular hydrogen bonds, and van der Waals forces, and it is opposed by conformational entropy.