Compare the interaction between D151 and amino group of oseltamivir carboxylate.
From the nature.com
The oxidation pathway starts with the removal of the amino group by a transaminase.
From the en.wikipedia.org
However, x-ray analysis showed that Asp235 is also critical for holding the amino group of alanine.
From the sciencedaily.com
In this system, both the amino group of oseltamivir carboxylate and the H150 imidazole side chain are in neutral states.
From the nature.com
The amino group is fed into the urea cycle, leaving a deaminated carbon skeleton in the form of a keto acid.
From the en.wikipedia.org
Deamidation is the reaction by which a glutamate residue is formed by cleavage of the epsilon-amino group of a glutamine side chain.
From the en.wikipedia.org
Additionally, the interaction between the side chain of D151 and the amino group of oseltamivir carboxylate is another factor that stabilizes the 150-loop in a closed conformation.
From the nature.com
The positively charged oseltamivir carboxylate amino group forms a hydrogen bond with the D151 side chain, which stabilizes the closed 150-loop conformation.
From the nature.com
It is believed that this reacts with the amino group of the side chain of lysine residues in proteins, causing cross-linking and a loss of protein function.